Parkinson's disease is a complex health condition characterised by a degeneration of dopaminergic neurons of the brain. This movie explains the dynamics of molecular reorganisation occurring at the synaptic level after the loss of those neurons.
Accumulating evidence indicates that L-DOPA-induced dyskinesia is primarily caused by the sensitization of dopamine D1 receptor transmission in striatal medium spiny neurons. This phenomenon, combined with chronic administration of L-DOPA, leads to persistent and intermittent hyper-activation of the cAMP signaling cascade.
The movie produced in collaboration with Dr. Bezard pictures the precise molecular mechanisms taking place in healthy subject and their impairment in the parkinsonian condition including L-DOPA induced dyskinesia. Neurodegenerative illnesses such as Parkinson's Disease affect many human lives and communities from patients and their families to clinicians and researchers. Animation is a powerful tool to turn complex biological reality into meaningful graphics for the both scientist, patients and the general public.