Dr Katalin Toth investigates the mechanisms governing synaptic short-term plasticity at mossy fiber to CA3 pyramidal cell synapses using a combination of state-of-the-art electrophysiological and imaging techniques. Their findings suggest that the combination of multivesicular release and the recruitment of additional release sites act together to increase glutamate release during burst activity. This is supported by the compartmentalized spatial profile of calcium elevations in boutons and helps to expand the dynamic range of mossy fibers information transfer.
Synaptic short-term plasticity at mossy fiber to CA3 pyramidal cell synapses
Area of expertise:
Mossy Fiber Bouton
Dr Katalin Toth, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Quebec
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